Aging of the Other Genome: A Decisive but Ambitious Solution
Google Tech Talks December, 19 2007 The DNA in our cells consists of not only the well-known 46 chromosomes currently receiving such avid attention from specialists in sequencing technology, but also a large number of copies of a relatively tiny, circular DNA molecule inside the "powerhouse of the cell," the mitochondrion. Among other things, mitochondria perform the chemistry of breathing – they extract energy from nutrients by exquisitely regulated chemical reactions that consume oxygen and create CO2. This vital function depends on the 13 proteins encoded by the mitochondrial DNA (mtDNA), as well as on hundreds of proteins that are encoded in our more famous genome and imported across the mitochondrial surface after construction in the body of the cell. The mtDNA accumulates mutant, non-functional variants far faster than our main genome, so 20 years ago scientists began looking at the idea of putting copies of the 13 genes of interest into the nucleus after making modifications that would cause them to be processed by the same “protein import” machinery that processes the mitochondrion’s many other proteins, thus making the mtDNA itself superfluous and mutations in it harmless. I will discuss this concept in detail in my talk. Progress has been very erratic in the meantime but is now very rapid, partly because of Methuselah Foundation-funded research. However, this approach may still prove impossible, so many other, ostensibly simpler ideas – some more …
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April 13th, 2010 at 6:23 pm
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have a shave man D
April 14th, 2010 at 4:13 pm
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Is there is a thing of the pathology of the mind? It is the software that effects the body or macrocosm.
April 16th, 2010 at 9:14 pm
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If I had money I would give it all to his research.
April 19th, 2010 at 4:10 am
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Mitochondrial condition is not the only causative agent in aging; for example, Dolly the cloned sheep suffered from premature aging. Dollys DNA came from a donor while Dollys mitochondria came from her surrogate mother, thus the cause of the aging was not the mitochondria but from the pre-aged donor DNA. Cause: maybe telomere shortening.
April 21st, 2010 at 4:00 am
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and it will be cured.
April 24th, 2010 at 1:52 pm
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aging is a terminal illness that we are all born with.
April 24th, 2010 at 6:51 pm
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He’s a joke, he hasn’t done any research and is all theory, he’s got a complete theory on why we age but knows nothing on how to actually stop it.
April 25th, 2010 at 2:25 pm
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Support Aubrey de Grey’s research to defeat aging
.
Join 3w [dot] causes [dot] com/defeataging
April 28th, 2010 at 1:57 pm
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Agreed. Every read some of Heinlein’s books like “The Cat Who Walks Through Walls”, or “To Sail Beyond the Sunset”. We really are coming up on a time when we will be rejuvenated every so many years.
April 28th, 2010 at 7:34 pm
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aging is a huge burden on humanity. it’s a curse that we are all born with. It will also be cured.
April 29th, 2010 at 10:36 am
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@Jogeta5 I hope (for him) his wife doesn’t like glans’ piercing
April 29th, 2010 at 6:04 pm
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@tonyhoffmans Don’t know about Aubrey specifically, but the Methuselah Foundation is definitely still kicking around. Excited to see what the next wave of PR is whenever it arrives.
May 2nd, 2010 at 10:04 pm
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Modern da Vinci.
May 3rd, 2010 at 4:23 pm
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I will not die for death will be dead when I am old to enough die—M.Osman
May 5th, 2010 at 11:11 pm
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Aging is a barbaric phenomenon
May 9th, 2010 at 7:34 am
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Imgine Wolverine with cancer…gross^^
May 9th, 2010 at 11:35 am
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He keep the beard because his wife likes it.
May 12th, 2010 at 6:24 am
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dawwg shave yr shit mannn
May 13th, 2010 at 6:15 pm
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swedish accent
May 16th, 2010 at 1:42 am
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am searching for vids… he might be planning a very big speech about ending aging.
May 18th, 2010 at 12:17 am
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so does anyone whatever happend to this guy? any updates on his research or new vids?
May 20th, 2010 at 6:25 pm
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This is moving in the right direction! This man is working toward progress. The least we could do is support him.
May 22nd, 2010 at 4:53 am
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we must cure aging.
aging kills 100,000 a day. if you care about saving lives.
target a way to stop ourselves from growing old!
May 22nd, 2010 at 5:25 am
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i agree!!!!
remember in the 1970s the average life span was like what less then 68 in the unitedstates?? people had babies at age 28 on average and had on average higher then 2 per family
now its like 80 in the us as of 2009 and people have babies in the late 30s, and the average birth rate here i think is 1.7
May 25th, 2010 at 12:03 am
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The longer and healthier lives people have, the lower the birth rate is. It’s been happening for a century now.